edition. Triton, 2001. ISBN 80-7254-181-1. Neuromuscular blockade, nondepolarizing (treatment)Parenteral neostigmine 10, 11, 12, 14, 16, 34 and pyridostigmine 8, 9 are indicated as antidotes to. Oximes must be administered in a timely manner (e.g. follows: Neostigmine Give atropine 0.6 mg (0.02 mg/kg in children up to 0.6 mg) or glycopyrrolate (0.2 mg per 1 mg neostigmine dose) immediately prior to neostigmine. Once it loses them, it forms a covalent bond with ACHE, the bond is irreversible. It is important to administer IV neostigmine slowly and have atropine. They are able to bind the organophosphate, which has all the side structures, and tear it away from ACHE. Atropine sulfate should be readily available whenever cholinergic drugs are given.
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